enetic testing in hypertrophic cardiomyopathy (HCM) is a revealed guideline-based advice. The diagnostic yield of genetic testing and corresponding HCM-associated genes have been largely documented by single middle research and thoroughly chosen affected person cohorts. Our aim was to judge the diagnostic yield of genetic testing in a heterogeneous cohort of patients with a medical suspicion of HCM, referred for genetic testing from a number of facilities all over the world.
A retrospective evaluate of patients with a suspected medical analysis of HCM referred for genetic testing at Blueprint Genetics was undertaken. The evaluation included syndromic, myopathic and metabolic etiologies. Genetic take a look at outcomes and variant classifications have been extracted from the database. Variants categorized as pathogenic (P) or doubtless pathogenic (LP) have been thought of diagnostic. A complete of 1376 samples have been analyzed. Three hundred and sixty-nine exams have been diagnostic (26.8%); 373 P or LP variants have been recognized. Only one copy quantity variant was recognized.
The majority of diagnostic variants concerned genes encoding the sarcomere (85.0%) adopted by 4.3% of diagnostic variants recognized in the RASopathy genes. Two % of diagnostic variants have been in genes related to a cardiomyopathy aside from HCM or an inherited arrhythmia. Clinical variables that elevated the chance of figuring out a diagnostic variant included: an earlier age at analysis (p < 0.0001), a increased most wall thickness (MWT) (p < 0.0001), a optimistic household historical past (p < 0.0001), the absence of hypertension (p = 0.0002), and the presence of an implantable cardioverter-defibrillator (ICD) (p = 0.0004). 
The diagnostic yield of genetic testing in this heterogeneous cohort of patients with a medical suspicion of HCM is decrease than what has been reported in well-characterized affected person cohorts. We report the best yield of diagnostic variants in the RASopathy genes recognized in a laboratory cohort of HCM patients thus far. The spectrum of genes implicated in this unselected cohort highlights the significance of pre-and post-test counseling when providing genetic testing to the broad HCM inhabitants.

Australia and New Zealand renal gene panel testing in routine medical apply of 542 households

Genetic testing in nephrology medical apply has moved quickly from a uncommon specialised take a look at to routine apply each in pediatric and grownup nephrology. However, clear info pertaining to the doubtless end result of testing continues to be lacking. Here we describe the expertise of the accredited Australia and New Zealand Renal Gene Panels medical service, reporting on sequencing for 552 people from 542 households with suspected kidney illness in Australia and New Zealand. An growing quantity of referrals have been processed since service inception with an general diagnostic fee of 35%.

The chance of figuring out a causative variant varies based on each age at referral and gene panel. Although outcomes from excessive throughput genetic testing have been primarily for diagnostic functions, they’ll more and more play an vital function in directing remedy, genetic counseling, and household planning. The advantages of no-cost genetic testing initiatives haven’t been characterised. The no-cost My Retina Tracker Genetic Testing Study (MRT-GTS) analysis registry for inherited retinal degenerations (IRDs) was launched in 2017 in the US.

Here, we report the event of a novel assay, which we time period the PluriLum assay, the place we now have launched a luciferase reporter gene into the locus of NKX2.5 of our hiPSC line. This enabled us to measure luminescence intensities as an alternative of counting beating cardiomyocytes, which is much less labor intensive. We established two NKX2.5 reporter cell strains and validated their pluripotency and genetic stability. Moreover, we confirmed that the genetically engineered NKX2.5 reporter cell line differentiated into cardiomyocytes with the identical effectivity as the unique wild-type line.

We then uncovered the cells to valproic acid (25-300 μM) and thalidomide (0.1-36 µM) and in contrast the PluriBeat readout of the cardiomyocytes with the luminescence depth of the PluriLum assay. The outcomes confirmed that thalidomide decreased luminescence depth considerably with a increased efficiency and efficacy in comparison with the beating readout. With this, we now have developed a novel hiPSC-based assay with a standardized readout that will have the potential for increased throughput screening for developmental toxicity.

Diagnostic yield of genetic testing in a heterogeneous cohort of 1376 HCM patients

Trophectoderm biopsy protocols might influence the speed of mosaic blastocysts in cycles with pre-implantation genetic testing for aneuploidy

This research aimed to investigate the influence of completely different biopsy protocols on the speed of mosaic blastocysts. This is a retrospective cohort research which included 115 cycles with pre-implantation genetic testing for aneuploidy (PGT-A). Two teams have been allotted based mostly on the biopsy protocols: technique 1 group, the zona pellucida (ZP) was drilled on day Three embryos adopted by trophectoderm (TE) biopsy; and technique 2 group, the ZP was opened on day 5 or 6 blastocysts adopted by TE biopsy. All biopsy samples have been assessed utilizing next-generation sequencing (NGS) at a single reference laboratory. The euploid, aneuploid, and mosaic blastocyst charges and medical outcomes have been in contrast.
The mosaicism fee in the strategy 1 group was 19.58%, considerably increased than the strategy 2 group (8.12%; P < 0.05). No statistically vital distinction was noticed in euploid, aneuploid blastocyst charges, and medical being pregnant charges between the 2 teams. Logistic regression evaluation indicated that the biopsy protocols have been independently related to the mosaicism charges amongst all of the variables. The current research confirmed that completely different biopsy protocols might have an effect on the mosaic blastocyst fee. ZP opening on day Three mixed with TE biopsy may improve the incidence of mosaic blastocysts.
Water, distilled
GK8002-1L 1 l
EUR 38
Water, distilled
GK8002-5L 5 l
EUR 54
PEPTONE WATER
P16-103-10kg 10 kg
EUR 666
PEPTONE WATER
P16-103-2Kg 2 Kg
EUR 184
PEPTONE WATER
P16-103-500g 500 g
EUR 86
Distilled Water
W0325-050 500 ml
EUR 64
Distilled Water
W0325-100 1L
EUR 69
DEPC Water
DD1005(D0121) 500ml
EUR 61.31
  • Product category: Biochemicals/Biology Reagents/RNA Related
Water, deionized
WC8800 4L
EUR 84.36
  • Product category: Culture Media/Water - Culture Grade
Water, autoclaved
WW1001 4L
EUR 69.79
  • Product category: Culture Media/Water - Culture Grade
TOMATO PASTE TESTING BROTH
T20-119-10kg 10 kg
EUR 739
TOMATO PASTE TESTING BROTH
T20-119-2Kg 2 Kg
EUR 200
TOMATO PASTE TESTING BROTH
T20-119-500g 500 g
EUR 91
Digitonin, Water-Soluble
2081-100
EUR 175
Digitonin, Water-Soluble
2081-1000
EUR 669
Digitonin, Water-Soluble
2081-250
EUR 294
Digitonin, Water-Soluble
2081-5000 Ask for price
BUFFERED PEPTONE WATER
B02-121-10kg 10 kg
EUR 785
BUFFERED PEPTONE WATER
B02-121-2kg 2kg
EUR 209
BUFFERED PEPTONE WATER
B02-121-500g 500 g
EUR 93
Water, Deionized/Distilled
DDH-20000 20 L
EUR 112
Water, Deionized/Distilled
DDH3800 1 Gal.
EUR 90
Water, Deionized/Distilled
DDH999 1000 ml
EUR 72
RNase-Free water
abx098145-25ml 25 ml
EUR 175
  • Shipped within 5-10 working days.
water hardness electrode
ISE37B ea
EUR 352
Water, PCR Certified
W0806-010 100ml
EUR 88
Water, PCR Certified
W0806-050 500ml
EUR 112
Water, PCR Certified
W0806-100 10x10ml
EUR 97
Purified Water, 50ML
X137-50ML 50ML
EUR 122
DEPC-Treated Water
M1500-1000 1000 ml
EUR 196
DEPC-Treated Water
M1500-500 500 ml
EUR 146
Digitonin-Water-soluble
DG1152 100mg
EUR 224
  • Product category: Biochemicals/Detergents/Surfactants
Frit Kit
FRIT-KIT 1each
EUR 124
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.
Column Packing Kit
PACK-KIT 1pack
EUR 1035
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.
PCR Mycoplasma Detection Kit
M034-Kit Kit
EUR 266
Peroxide Quantitative Assay Kit (Water compatible)
BSP069 250Assays, 250preps
EUR 91.76
  • Product category: Molecular Biology Kits/Protein - Assays/Peroxide based
Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit
CAS400A-KIT 1 kit (10 rxn)
EUR 1110
  • Category: Cas9
KN-93, Water-Soluble
1909-1
EUR 191
KN-93, Water-Soluble
1909-5
EUR 533
BUFFERED PEPTONE WATER (ISO)
B02-130-10kg 10 kg
EUR 957
BUFFERED PEPTONE WATER (ISO)
B02-130-2kg 2kg
EUR 247
BUFFERED PEPTONE WATER (ISO)
B02-130-500g 500 g
EUR 104
ToxOut? Endotoxin Free Water
7938-50
EUR 153
Water, Cell Culture Grade
CA018-600 6x1000ml
EUR 124
Water (Molecular Biology Grade)
CE243 500 ml
EUR 52
Water (Molecular Biology Grade)
CE244 1 l
EUR 56
PCR Water 10x1.8 ml
BA01201 10x1.8ml
EUR 87
Description: PCR grade ultra pure water.
PCR Water 25x1.8 ml
BA01202 25x1.8ml
EUR 123
Description: PCR grade ultra pure water.
PCR Water 5x10 ml
BA01203 5x10ml
EUR 123
Description: PCR grade ultra pure water.
Isopropanol, 70% in water
GE9802-1L 1 l
EUR 66
Isopropanol, 70% in water
GE9802-2500ML 2500 ml
EUR 102
cal. solution water hardness
ISC37 ea
EUR 91
1L DEPC Treated Water
NAT1104 1L
EUR 100
CMV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit
CASLV100PA-KIT 1 Kit
EUR 1132
  • Category: Cas9
CMV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit
CASLV105PA-KIT 1 Kit
EUR 1132
  • Category: Cas9
MSCV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit
CASLV120PA-KIT 1 Kit
EUR 1132
  • Category: Cas9
MSCV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit
CASLV125PA-KIT 1 Kit
EUR 1132
  • Category: Cas9
Multiplex gRNA Kit + EF1-T7-hspCas9-H1-gRNA linearized SmartNuclease vector
CAS700A-KIT 10 rxn
EUR 1132
  • Category: Cas9
Multiplex gRNA Kit + CAG-T7-hspCas9-H1-gRNA linearized SmartNuclease vector
CAS720A-KIT 10 rxn
EUR 1132
  • Category: Cas9
Multiplex gRNA Kit + CMV-T7-hspCas9-H1-gRNA linearized SmartNuclease vector
CAS740A-KIT 10 rxn
EUR 1132
  • Category: Cas9
T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents)
CAS510A-KIT 1 Kit
EUR 805
  • Category: Cas9
Cas9 Nickase: CMV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit
CASLV200PA-KIT 1 Kit
EUR 1132
  • Category: Cas9
Cas9 Nickase: CMV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit
CASLV205PA-KIT 1 Kit
EUR 1132
  • Category: Cas9
Cas9 Nickase: MSCV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit
CASLV220PA-KIT 1 Kit
EUR 1132
  • Category: Cas9
Cas9 Nickase: MSCV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit
CASLV225PA-KIT 1 Kit
EUR 1132
  • Category: Cas9
Multiplex gRNA Kit + Cas9 Nickase: EF1-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector
CAS750A-KIT 10 rxn
EUR 1132
  • Category: Cas9
Multiplex gRNA Kit + Cas9 Nickase: CAG-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector
CAS770A-KIT 10 rxn
EUR 1132
  • Category: Cas9
Multiplex gRNA Kit + Cas9 Nickase: CMV-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector
CAS790A-KIT 10 rxn
EUR 1132
  • Category: Cas9
Cas9 SmartNuclease Extra Ligation Kit [includes 5x ligation buffer (10 ul) and Fast ligase (2.5ul)]
CAS9LIG-KIT 1 Kit
EUR 153
  • Category: Cas9
Adipose Protein Fractionation Kit (water-soluble/insoluble)
P523-2 NULL
EUR 0
Adipose Protein Fractionation Kit (water-soluble/insoluble)
P523-20 NULL
EUR 0
Adipose Protein Fractionation Kit (water-soluble/insoluble)
P523-80 NULL
EUR 0
PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (includes PIN320A-1, PIN200A-1, PIN510A-1 & PIN600A-1)
PIN320A-KIT 1 Kit
EUR 4941
  • Category: PinPoint Integrase Tools
PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (includes PIN340iPS-1, PIN200A-1, PIN510A-1 & PIN600A-1)
PIN340iPS-KIT 1 Kit
EUR 4941
  • Category: PinPoint Integrase Tools
Custom Testing of samples for Rituximab/Rituxan ELISA Kit
200-210-CUX Custom
EUR 1138
EvaGreen, 20X in water: (5x1mL)
31000 5x1ML
EUR 260
Description: Minimum order quantity: 1 unit of 5x1ML
DIGITAL WATER BATH, 6L, 120V
6783 1/pk
EUR 652
Description: Lab Equipment; Constant Temperature Equipment
Water, Ultrapure Molecular Biology Grade
41024-4L 4L
EUR 121
Description: Minimum order quantity: 1 unit of 4L
RedDot 1, 200X in water
40060 250uL
EUR 262
Description: Minimum order quantity: 1 unit of 250uL
RedDot 1, 200X in water
40060-1 1mL
EUR 467
Description: Minimum order quantity: 1 unit of 1mL
RedDot 1, 200X in water
40060-T 25uL
EUR 106
Description: Minimum order quantity: 1 unit of 25uL
Isethionic acid (80% in water)
20-abx186019
  • EUR 258.00
  • EUR 217.00
  • 100 g
  • 25 g
  • Shipped within 1-2 weeks.
DEPC- treated Water 5x1.8 ml
BA01204 5x1.8ml
EUR 87
Description: PCR grade ultra pure water.
Glutaraldehyde solution, 25% in water
GC0694-100ML 100 ml
EUR 42
Glutaraldehyde solution, 25% in water
GC0694-500ML 500 ml
EUR 62
Glutaraldehyde solution, 50% in water
GC4387-100ML 100 ml
EUR 46
Glutaraldehyde solution, 50% in water
GC4387-500ML 500 ml
EUR 70
Hydrogen peroxide, 6% in water
GE3243-100G 100 g
EUR 46
Hydrogen peroxide, 6% in water
GE3243-500G 500 g
EUR 62
Fish gelatin (cold water fish)
GELF14-N-50 50 ml
EUR 103
Didecyldimethylammonium chloride, 50% in water
GK0001-1L 1 l
EUR 146
Didecyldimethylammonium chloride, 50% in water
GK0001-500ML 500 ml
EUR 94
Water-Resistant, Traceable Flashing Timer
LE9004 Ea
EUR 80
SB-12L Shaking Water Bath
SB0012-E 1 PC
EUR 131.99
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.
Distilled Water, 2.5 Gal (9.47L)
W0325-250 2.5 Gal
EUR 93
UltraPure Water, Cell Culture Tested
W9200-045 450ml
EUR 80
2L Digital Water Bath, 115V
BCM1400 1 pcs, 1 UNIT
EUR 798.83
  • Product category: Benchtop Equipment/Water Baths
4L Digital Water Bath, 115V
BCM1401 1 pcs, 1 UNIT
EUR 1119.28
  • Product category: Benchtop Equipment/Water Baths
8L Digital Water Bath, 115V
BCM1402 1 pcs, 1 UNIT
EUR 1214.18
  • Product category: Benchtop Equipment/Water Baths
12L Digital Water Bath, 115V
BCM1403 1 pcs, 1 UNIT
EUR 1432.33
  • Product category: Benchtop Equipment/Water Baths
Phenol-liquid, saturated with water
PC5523 100ml
EUR 91.76
  • Product category: Biochemicals/Solvents
AAVS1 Safe Harbor Targeting Vector 2.0 - All-Purpose Donor (AAVS1-SA-puro-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)
GE620A-KIT 1 kit
EUR 2132
  • Category: Gene Editing
AAVS1 Safe Harbor Targeting Vector 2.0 - GOI Knock-in Donor (AAVS1-SA-puro-EF1-MCS), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)
GE622A-KIT 1 kit
EUR 2132
  • Category: Gene Editing
AAVS1 Safe Harbor Targeting Vector 2.0 - Reporter Knock-in Donor (AAVS1-SA-puro-MCS-GFP), Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector) and GE640PR-1 (Junction PCR Primer Mix to confirm AAVS1 integration site)
GE624A-KIT 1 kit
EUR 2132
  • Category: Gene Editing
Porcine Selenide, water dikinase 2, SEPHS2 ELISA KIT
ELI-13944p 96 Tests
EUR 928
Mouse Selenide, water dikinase 2, Sephs2 ELISA KIT
ELI-19110m 96 Tests
EUR 865
Human Selenide, water dikinase 2, SEPHS2 ELISA KIT
ELI-30043h 96 Tests
EUR 824
Mouse Selenide, water dikinase 1, Sephs1 ELISA KIT
ELI-53429m 96 Tests
EUR 865
Bovine Selenide, water dikinase 1, SEPHS1 ELISA KIT
ELI-41213b 96 Tests
EUR 928
Human Selenide, water dikinase 1, SEPHS1 ELISA KIT
ELI-41214h 96 Tests
EUR 824
100 ML, MOLECULAR BIOLOGY GRADE WATER; TESTED TO USP STERILE PURIFIED WATER SPECIFICATIONS
46-000-CI 100 mL/pk
EUR 57
Description: Media Catalog; Sterile Wi-Fi Qual, Cell
1 L, MOLECULAR BIOLOGY GRADE WATER; TESTED TO USP STERILE PURIFIED WATER SPECIFICATIONS
46-000-CM 1L/pk
EUR 98
Description: Media Catalog; Sterile Wi-Fi Qual, Cell
500 ML, MOLECULAR BIOLOGY GRADE WATER; TESTED TO USP STERILE PURIFIED WATER SPECIFICATIONS
46-000-CV 500 mL/pk
EUR 106
Description: Media Catalog; Sterile Wi-Fi Qual, Cell
vWF Acty. Kit
ABP-ACT-KIT 12 x 8 microwells
EUR 428
vWF Ant. Kit
ABP-TOT-KIT 12 x 8 microwells
EUR 394
100 ML, CELL CULTURE GRADE WATER; TESTED TO USP STERILE WATER FOR INJECTION SPECIFICATIONS
25-055-CI 100 mL/pk
EUR 58
Description: Media Catalog; Sterile Wi-Fi Qual, Cell
1 L, CELL CULTURE GRADE WATER; TESTED TO USP STERILE WATER FOR INJECTION SPECIFICATIONS
25-055-CM 1 L/pk
EUR 72
Description: Media Catalog; Sterile Wi-Fi Qual, Cell
500 ML, CELL CULTURE GRADE WATER; TESTED TO USP STERILE WATER FOR INJECTION SPECIFICATIONS
25-055-CV 500 mL/pk
EUR 59
Description: Media Catalog; Sterile Wi-Fi Qual, Cell
20 L, CELL CULTURE GRADE WATER; TESTED TO USP STERILE WATER FOR INJECTION SPECIFICATIONS
25-055-LB 20 L/pk
EUR 210
Description: Media Catalog; Sterile Wi-Fi Qual, Cell
100 L, CELL CULTURE GRADE WATER; TESTED TO USP STERILE WATER FOR INJECTION SPECIFICATIONS
25-055-LG 100 L/pk
EUR 792
Description: Media Catalog; Sterile Wi-Fi Qual, Cell
200 L,CELL CULTURE GRADE WATER; TESTED TO USP STERILE WATER FOR INJECTION SPECIFICATIONS
25-055-LH 200 L/pk
EUR 1159
Description: Media Catalog; Sterile Wi-Fi Qual, Cell
hspCas9 AAVS1 Safe Harbor Knock-in Donor (AAVS1-SA-puro-EF1-hspCas9)
CAS620A-KIT 1 kit
EUR 2152
  • Category: Cas9
Description: Complete Kit with CAS601A-1 (Cas9 SmartNuclease AAVS1-gRNA Targeting Vector), CAS640PR-1 (Junction PCR Primer Mix to confirm Cas9 integration site), and CAS9-PR-1 (PCR primers to confirm Cas9 expression)
PinPoint-FC System for Platform Cell Line Generation & Retargeting (includes PIN300A-1, FC200PA-1, PIN200A-1, PIN510A-1, & PIN600A-1)
PIN300A-KIT 1 Kit
EUR 2798
  • Category: PinPoint Integrase Tools
PinPoint-HR System for Platform Cell Line Generation & Retargeting (includes PIN400A-1, PIN200A-1, PIN510A-1, & PIN600A-1)
PIN400A-KIT 1 Kit
EUR 2798
  • Category: PinPoint Integrase Tools
PinPoint-HR System for Platform Cell Line Generation & Retargeting of AAVS1 Safe Harbor Locus (includes PIN410A-1, GE601A-1, PIN200A-1, PIN510A-1, & PIN600A-1)
PIN410A-KIT 1 Kit
EUR 4335
  • Category: PinPoint Integrase Tools
PinPoint-HR System for Platform Cell Line Generation & Retargeting of AAVS1 Safe Harbor Locus (includes PIN410A-1, CAS601A-1, PIN200A-1, PIN510A-1, & PIN600A-1)
PIN412A-KIT 1 Kit
EUR 4335
  • Category: PinPoint Integrase Tools
Probenecid, sodium salt *water soluble*: (10x77mg)
50027 10MG
EUR 236
Description: Minimum order quantity: 1 unit of 10MG
4 L REAGENT GRADE WATER, CUBE
46-002-LF 4 L/pk
EUR 91
Description: Media Catalog; Sterile Wi-Fi Qual, Cell
Acridine Orange, 10mg/mL in water
40039 10ML
EUR 101
Description: Minimum order quantity: 1 unit of 10ML
Human Selenide, water dikinase 1 (SEPHS1)
1-CSB-EP021015HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 69.8 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Selenide, water dikinase 1(SEPHS1) expressed in E.coli
Tris(trifluoroMethanesulfonyl)Methane, 70% in water
20-abx185605
  • EUR 954.00
  • EUR 481.00
  • 1 g
  • 250 mg
  • Shipped within 1-2 weeks.
Methylene Blue solution, 0.5% in water
GT8594-100ML 100 ml
EUR 38
Methylene Blue solution, 0.5% in water
GT8594-1L 1 l
EUR 50
Methylene Blue solution, 0.5% in water
GT8594-500ML 500 ml
EUR 42
Ethidium bromide, 10mg/ml in water
GT9211-10ML 10 ml
EUR 70
Brij 35, 10% solution in water
GD6153-100ML 100 ml
EUR 62
To take a look at giant numbers of chemical compounds for developmental toxicity, fast in vitro exams with standardized readouts for automated information acquisition are wanted. However, probably the most broadly used assay, the embryonic stem cell take a look at, depends on the counting of beating embryoid our bodies by visible inspection, which is laborious and time consuming. We beforehand developed the PluriBeat assay based mostly on differentiation of human induced pluripotent stem cells (hiPSC) that we demonstrated to be predictive for identified teratogens at related concentrations utilizing the readout of beating cardiomyocytes.