Complement factor C4 exists as two main isotypes, C4A and C4B, with different functional properties and encoded by two separate genes. In addition, C4A and C4B genes can occur in multiple copies and may carry a retroviral HERV-K(C4) insertion in intron 9.
To study association of C4 polymorphism with disease, accurate genotyping and phenotyping is important. However, current techniques are very laborious and not suitable to study large patient groups.
 Acetaminophen metabolite 3-hydroxy-acetaminophen |
|
HY-G0004 |
MedChemExpress |
10mM/1mL |
EUR 176 |
, Clone: COX 229) Monoclonal PTGS2 / COX2 / COX-2 Antibody (clone COX 229), Clone: COX 229 |
|
AMR09628G |
Leading Biology |
0.1ml |
EUR 484 |
|
Description: A Monoclonal antibody against Human PTGS2 / COX2 / COX-2 (clone COX 229). The antibodies are raised in Mouse and are from clone COX 229. This antibody is applicable in IHC-P, IHC-Fr |
 COX IV Antibody |
|
49275-100ul |
SAB |
100ul |
EUR 333 |
COX IV Antibody |
|
49275-50ul |
SAB |
50ul |
EUR 239 |
COX IV Antibody |
|
AF5468 |
Affbiotech |
200ul |
EUR 304 |
|
Description: COX IV antibody detects endogenous levels of total COX IV. |
 anti-COX IV |
|
YF-PA11035 |
Abfrontier |
50 ug |
EUR 363 |
|
Description: Mouse polyclonal to COX IV |
anti-COX IV |
|
YF-PA11036 |
Abfrontier |
100 ug |
EUR 403 |
|
Description: Rabbit polyclonal to COX IV |
anti-COX IV |
|
YF-PA23493 |
Abfrontier |
50 ul |
EUR 334 |
|
Description: Mouse polyclonal to COX IV |
 Cox 4 antibody |
|
20R-1683 |
Fitzgerald |
100 ug |
EUR 673 |
|
Description: Rabbit polyclonal Cox 4 antibody |
 Cox 3 antibody |
|
20R-1705 |
Fitzgerald |
100 ug |
EUR 673 |
|
Description: Rabbit polyclonal Cox 3 antibody |
 Cox 1 antibody |
|
20R-1525 |
Fitzgerald |
100 ug |
EUR 673 |
|
Description: Rabbit polyclonal Cox 1 antibody |
 Cox 2 antibody |
|
20R-1526 |
Fitzgerald |
100 ug |
EUR 673 |
|
Description: Rabbit polyclonal Cox 2 antibody |
 COX-1 Peptide |
|
45-124P |
ProSci |
0.1 mg |
EUR 338 |
|
Description: (CT) COX1 / COX-1 Peptide |
 COX-2 Peptide |
|
45-125P |
ProSci |
0.1 mg |
EUR 338 |
|
Description: (CT) COX2 / COX-2 Peptide |
 Cox-1 Polyclonal Antibody |
|
ES2032-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against Cox-1 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
Cox-1 Polyclonal Antibody |
|
ES2032-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against Cox-1 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
 Cox-2 Polyclonal Antibody |
|
ES2034-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against Cox-2 from Human. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
Cox-2 Polyclonal Antibody |
|
ES2034-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against Cox-2 from Human. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
 COX IV Polyclonal Antibody |
|
EA150-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against COX IV from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC |
COX IV Polyclonal Antibody |
|
EA150-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against COX IV from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC |
 Anti-Cox-2 Antibody |
|
A00084-1 |
BosterBio |
100uL |
EUR 455 |
|
Description: Rabbit Polyclonal antibody for PTGS2, COX2 detection. Tested positive for ELISA,Immunohistochemistry,Western Blot, in human, mouse, rat |
 COX IV Rabbit mAb |
|
A11631-100ul |
Abclonal |
100 ul |
EUR 410 |
COX IV Rabbit mAb |
|
A11631-200ul |
Abclonal |
200 ul |
EUR 571 |
COX IV Rabbit mAb |
|
A11631-20ul |
Abclonal |
20 ul |
EUR 221 |
COX IV Rabbit mAb |
|
A11631-50ul |
Abclonal |
50 ul |
EUR 287 |
 COX IV Mouse mAb |
|
A10098-100ul |
Abclonal |
100 ul |
EUR 384 |
COX IV Mouse mAb |
|
A10098-200ul |
Abclonal |
200 ul |
EUR 554 |
COX IV Mouse mAb |
|
A10098-20ul |
Abclonal |
20 ul |
Ask for price |
COX IV Mouse mAb |
|
A10098-50ul |
Abclonal |
50 ul |
EUR 265 |
Cox-1 Polyclonal Antibody |
|
ABP51033-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A polyclonal antibody for detection of Cox-1 from Human. This Cox-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Cox-1 at AA range: 520-600 |
Cox-1 Polyclonal Antibody |
|
ABP51033-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A polyclonal antibody for detection of Cox-1 from Human. This Cox-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Cox-1 at AA range: 520-600 |
Cox-1 Polyclonal Antibody |
|
ABP51033-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A polyclonal antibody for detection of Cox-1 from Human. This Cox-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Cox-1 at AA range: 520-600 |
Cox-2 Polyclonal Antibody |
|
ABP51035-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A polyclonal antibody for detection of Cox-2 from Human. This Cox-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Cox-2 at AA range: 530-610 |
Cox-2 Polyclonal Antibody |
|
ABP51035-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A polyclonal antibody for detection of Cox-2 from Human. This Cox-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Cox-2 at AA range: 530-610 |
Cox-2 Polyclonal Antibody |
|
ABP51035-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A polyclonal antibody for detection of Cox-2 from Human. This Cox-2 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Cox-2 at AA range: 530-610 |
 COX IV Rabbit pAb |
|
A6564-100ul |
Abclonal |
100 ul |
EUR 308 |
COX IV Rabbit pAb |
|
A6564-200ul |
Abclonal |
200 ul |
EUR 459 |
COX IV Rabbit pAb |
|
A6564-20ul |
Abclonal |
20 ul |
EUR 183 |
COX IV Rabbit pAb |
|
A6564-50ul |
Abclonal |
50 ul |
EUR 223 |
COX IV Rabbit pAb |
|
A1263-100ul |
Abclonal |
100 ul |
EUR 384 |
COX IV Rabbit pAb |
|
A1263-200ul |
Abclonal |
200 ul |
Ask for price |
COX IV Rabbit pAb |
|
A1263-20ul |
Abclonal |
20 ul |
Ask for price |
COX IV Rabbit pAb |
|
A1263-50ul |
Abclonal |
50 ul |
EUR 265 |
) COX-4 Antibody (Biotin) |
|
abx445406-100ug |
Abbexa |
100 ug |
EUR 578 |
|
|
) COX-4 Antibody (FITC) |
|
abx445407-100ug |
Abbexa |
100 ug |
EUR 565 |
|
|
) COX-4 Antibody (HRP) |
|
abx445408-100ug |
Abbexa |
100 ug |
EUR 565 |
|
|
 Anti-Cox-1 antibody |
|
STJ92432 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Cox-1. |
 Anti-Cox-2 antibody |
|
STJ92438 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Cox-2 is a protein encoded by the PTGS2 gene which is approximately 68,9 kDa. Cox-2 is localised to the endoplasmic reticulum membrane. It is involved in PEDF induced signalling, arachidonic acid metabolism, aspirin triggered resolvin E biosynthesis and cytokine signalling. It is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. Cox-2 is expressed in cytokines and mitogens. Mutations in the PTGS2 gene may result in colorectal adenoma and chronic pain. STJ92438 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Cox-2 protein. |
 Anti-COX IV antibody |
|
STJ99044 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Mouse monoclonal to COX IV. |
Anti-COX IV antibody |
|
STJ96935 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: COX IV is a protein encoded by the COX4I1 gene which is approximately 19,5 kDa. COX IV is localised to the mitochondrion inner membrane. It is involved in respiratory electron transport, metabolism, gene expression, cardiac muscle contraction, apoptosis and autophagy. It is the terminal enzyme of the mitochondrial respiratory chain and forms a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. COX IV is expressed ubiquitously in human tissue. Mutations in the COX4I1 gene may result in Calvarial hyperostosis. STJ96935 was developed from clone 6C8 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous COX IV protein. |
Cox-1 Polyclonal Antibody |
|
40780-100ul |
SAB |
100ul |
EUR 252 |
Cox-1 Polyclonal Antibody |
|
40780-50ul |
SAB |
50ul |
EUR 187 |
Cox-2 Polyclonal Antibody |
|
40781-100ul |
SAB |
100ul |
EUR 252 |
Cox-2 Polyclonal Antibody |
|
40781-50ul |
SAB |
50ul |
EUR 187 |
) Sulindac Sulfide (COX inhibitor) |
|
SIH-261-10MG |
Stressmarq |
10 mg |
EUR 168 |
|
|
|
Description: The substance Sulindac Sulfide is a cox inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is yellow solid which is soluble to 25 mM in DMSO, 3 mM in ethanol. |
Sulindac Sulfide (COX inhibitor) |
|
SIH-261-50MG |
Stressmarq |
50 mg |
EUR 433 |
|
|
|
Description: The substance Sulindac Sulfide is a cox inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is yellow solid which is soluble to 25 mM in DMSO, 3 mM in ethanol. |
 COX IV Monoclonal Antibody |
|
EM1032-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Mouse Monoclonal antibody against COX IV from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IF |
COX IV Monoclonal Antibody |
|
EM1032-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Mouse Monoclonal antibody against COX IV from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IF |
 COX IV Conjugated Antibody |
|
C49275 |
SAB |
100ul |
EUR 397 |
 Monoclonal COX IV Antibody |
|
APG02703G |
Leading Biology |
0.1ml |
EUR 484 |
|
Description: A Monoclonal antibody against Human COX IV. The antibodies are raised in Mouse. This antibody is applicable in WB, ICC, IP, FC |
 Polyclonal Cox-2 Antibody |
|
APG02704G |
Leading Biology |
0.1mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Cox-2 . This antibody is tested and proven to work in the following applications: |
 Polyclonal Cox-4 Antibody |
|
APG02705G |
Leading Biology |
0.1mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Cox-4 . This antibody is tested and proven to work in the following applications: |
 Polyclonal Cox-1 Antibody |
|
APR00081G |
Leading Biology |
0.1mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Cox-1 . This antibody is tested and proven to work in the following applications: |
 Polyclonal Cox-3 Antibody |
|
APR00168G |
Leading Biology |
0.1mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Cox-3 . This antibody is tested and proven to work in the following applications: |
) COX-2 (Cyclooxygenase-2) |
|
MO47062 |
Neuromics |
100 ul |
EUR 349 |
COX IV Rabbit mAb |
|
A11631 |
Abclonal |
20 μL |
EUR 15 |
 Recombinant Human COX-1 |
|
P0525 |
FN Test |
100ug |
EUR 522.36 |
|
|
|
Description: Recombinant Human protein for COX-1 |
 COX IV Blocking Peptide |
|
AF5468-BP |
Affbiotech |
1mg |
EUR 195 |
 Cox-1 Blocking Peptide |
|
3361BP-50 |
Biovision |
|
EUR 153 |
 Cox-2 Blocking Peptide |
|
3362BP-50 |
Biovision |
|
EUR 153 |
Cox-2 Blocking Peptide |
|
3362RBP-50 |
Biovision |
|
EUR 153 |
 Cox-4 Blocking Peptide |
|
3638BP-50 |
Biovision |
|
EUR 153 |
 Cox-3 Blocking Peptide |
|
3687BP-50 |
Biovision |
|
EUR 153 |
) Anti-COX IV (4A10) |
|
YF-MA10182 |
Abfrontier |
100 ug |
EUR 363 |
|
Description: Mouse monoclonal to COX IV |
 Cox 1 Blocking Peptide |
|
33R-10474 |
Fitzgerald |
50 ug |
EUR 349 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Cox 1 antibody, catalog no. 20R-1525 |
 Cox 2 Blocking Peptide |
|
33R-10476 |
Fitzgerald |
50 ug |
EUR 349 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Cox 2 antibody, catalog no. 20R-1526 |
Therefore, we aimed to develop novel assays for C4 geno- and phenotyping, to make high throughput possible. To study C4 gene copy number variation, a novel Multiplex Ligation-dependent Probe Amplification (MLPA) assay was set up with three synthetic probe parts. C4A and C4B protein levels were measured by isotype-specific ELISA’s.
